Treatment with fixed thyroxine doses in pregnant women with subclinical hypothyroidism.
نویسندگان
چکیده
BACKGROUND Hypothyroidism is usually treated with thyroxine doses on patient weight. In some cases, however, fixed doses have proved to useful to normalize TSH levels, which is especially important during pregnancy. PATIENTS AND METHODS Sixty-eight women diagnosed with subclinical hypothyroidism, autoimmune or not, during pregnancy were given a fixed dose of thyroxine 50 mcg/day. TSH measurements were performed to assess the need to change the dose, which was increased or decreased by 25 mcg/day when necessary. RESULTS With a dose of 50 mcg/day of thyroxine, 42% of patients reached a TSH level less than 3 μU/mL, 79.4% reached a TSH level less than 4.5 μU/mL, and 20.6% had TSH levels higher than 4.5 μU/mL. DISCUSSION Our data suggest that a fixed dose of thyroxine 50 mcg/day is inadequate in a significant proportion of pregnancy-diagnosed hypothyroidism regardless of whether the reference of TSH level used is 4.5 or 3 μU/mL. S starting dose of 75 mcg/day is probably more adequate, but studies are needed to evaluate the possibility of overtreatment with such dose.
منابع مشابه
Treatment of subclinical hypothyroidism in pregnancy using fixed thyroxine daily doses of 75 μg.
BACKGROUND AND OBJECTIVES Treatment of hypothyroid pregnant women is usually calculated based on weight (1 μg/kg/day) and TSH levels. This study assessed the usefulness of treating these women with a fixed dose of 75 μg/day. PATIENTS AND METHODS All women with pregnancy diagnosed from January to August 2012 in the Vigo Health Area (Spain) without previous diagnosis of thyroid disease or thyro...
متن کاملThe Prevalence of Hypothyroidism Based on Risk Factors in Pregnant Women Referred to Shahid Dadbin Clinic, Kerman, Iran
Background & Aims: Since at early pregnancy (<20 week) fetal thyroid gland is undeveloped, normal development of the Fetal brain is highly dependent on maternal thyroid hormones. There are excessive adverse perinatal outcomes associated with overt and subclinical hypothyroidism such as increase of Abortion, preeclampsia, placenta Abruption, LBW, preterm labor, impaired fetal neuropsychological ...
متن کاملThe Effect of a Period of Aerobic Training on Serum Levels of IGF-1 and Thyroid Hormones in Women with Subclinical Hypothyroidism
Introduction: The IGF-1 affects physiological processes in the body and its serum levels decrease in patients with subclinical hypothyroidism. Therefore, the aim of this study was to investigate the effect of a period of aerobic training on serum levels of IGF-1 in women with subclinical hypothyroidism. Methods: In this quasi-experimental study, after obtaining written consents, 25 women with ...
متن کاملBeneficial Effects on Pregnancy Outcomes of Thyroid Hormone Replacement for Subclinical Hypothyroidism
Background. Hypothyroidism and raised thyroid antibody levels have been associated with adverse obstetrical outcomes. Several studies have investigated causal associations, but results have been inconsistent and few studies have reported the effects of thyroxine replacement therapy on pregnancy outcomes in hypothyroid patients. Objective. The primary study objective was to determine the outcome...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion
دوره 59 5 شماره
صفحات -
تاریخ انتشار 2012